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中文名称：
替诺福韦艾拉酚胺半富马酸盐(2:1);
别名：
GS-7340半富马酸盐;
英文名称：
Tenofovir Alafenamide Hemifumarate
英文别名：
GS-7340 Hemifumarate;
Tenofovir alafenamide fumarate, 2:1;
(E)-but-2-enedioic acid,propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-
phenoxyphosphoryl]amino]propanoate;
L-Alanine,N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-,1-methylethyl ester,(2E)-2-butenedioate (2:1);
GS-7340-03;
CAS号：1392275-56-7
分子式：C46H62N12O14P2
分子量：1069.00000
精确质量：1068.40000
PSA：381.18000
LogP：7.60180
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ITEM OF ANALYSIS |
STANDARD |
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Description |
White to off-white or tan powder |
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Identification |
IR: The IR absorption spectrum of the sample must be concordant with Test Standard |
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HPLC: The retention time of the major peak in the chromatogram conforms to the characteristic peak of R.S |
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Melting point |
128℃～134℃ |
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Water |
≤1.0% |
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Fumaric acid |
9.0%-13.0% |
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Heavy Metals |
≤20ppm |
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Related substances |
Single impurity≤0.2% |
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Total impurities≤1.0% |
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Isomer sum |
≤0.5% |
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Residue Solvents |
Meets current ICH requirements |
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Assay |
98.0%~102.0% |
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